Transcription initiation factor TFIID subunit 4B

Definition:

Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

References:

[1]. Özgecan Ayhan, et al. Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia. J Med Genet. 2014 Apr;51(4):239-44. [Content Brief]

[2]. Yimin Wu, et al. Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line. J Cell Biochem. 2005 Nov 1;96(4):751-9. [Content Brief]

[3]. O Wolstein, et al. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. J Biol Chem. 2000 Jun 2;275(22):16459-65. [Content Brief]

[4]. A Yamit-Hezi, et al. Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. J Biol Chem. 2000 Jun 16;275(24):18180-7. [Content Brief]

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