Transmembrane 6 superfamily member 2

Definition:

Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase.

References:

[1]. Luis Sanchez-Pulido, et al. TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease. Front Genet. 2014 Dec 11;5:439. [Content Brief]

[2]. Julia Kozlitina, et al. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2014 Apr;46(4):352-6. [Content Brief]

[3]. Hovsep Mahdessian, et al. TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8913-8. [Content Brief]

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