Transmembrane protein 168

Definition:

Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A. May play a role in the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens (By similarity).

References:

[1]. Akio Shimizu, et al. Identification of transmembrane protein 168 mutation in familial Brugada syndrome. FASEB J. 2020 May;34(5):6399-6417. [Content Brief]

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