Trophoblast glycoprotein

Definition:

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.

References:

[1]. Birgit Kagermeier-Schenk, et al. Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. Dev Cell. 2011 Dec 13;21(6):1129-43. [Content Brief]

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