Tropical calcific pancreatitis

Definition:

Tropical calcific pancreatitis (TCP) is a subtype of chronic pancreatitis unique to developing countries in tropical regions. Patients present with recurrent abdominal pain, nutritional deficiencies, and insulin-requiring diabetes resulting from chronic pancreatitis before age 30. Several environmental and genetic factors are implicated in TCP.

References:

[1]. D Nageshwar Reddy, et al. Genetic basis of chronic pancreatitis in Asia Pacific region. J Gastroenterol Hepatol. 2011 Mar;26 Suppl 2:2-5. [Content Brief]

[2]. G R Chandak, et al. Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. J Med Genet. 2002 May;39(5):347-51. [Content Brief]

[3]. Heiko Witt, et al. Genetic aspects of tropical calcific pancreatitis. Rev Endocr Metab Disord. 2008 Sep;9(3):213-26. [Content Brief]

[4]. Jonas Rosendahl, et al. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet. 2008 Jan;40(1):78-82. [Content Brief]

[5]. S Mahurkar, et al. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. Gut. 2006 Sep;55(9):1270-5. [Content Brief]

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