Tubulin polymerization-promoting protein family member 3

Definition:

Regulator of microtubule dynamic that has microtubule bundling activity. Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin.

References:

[1]. Wenbai Zhou, et al. Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation. Mol Cell Biochem. 2010 Jan;333(1-2):91-8. [Content Brief]

[2]. Orsolya Vincze, et al. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Biochemistry. 2006 Nov 21;45(46):13818-26. [Content Brief]

[3]. Vinay Shukla, et al. Inhibition of TPPP3 attenuates β-catenin/NF-κB/COX-2 signaling in endometrial stromal cells and impairs decidualization. J Endocrinol. 2019 Mar 1;240(3):417-429. [Content Brief]

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