Tumor protein 63

Definition:

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

References:

[1]. Shelya X Zeng, et al. SSRP1 functions as a co-activator of the transcriptional activator p63. EMBO J. 2002 Oct 15;21(20):5487-97. [Content Brief]

[2]. Yasushi Sasaki, et al. The p53 family member genes are involved in the Notch signal pathway. J Biol Chem. 2002 Jan 4;277(1):719-24. [Content Brief]

[3]. Karen Mitchell, et al. Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus. Am J Hum Genet. 2012 Jan 13;90(1):69-75. [Content Brief]

[4]. Zach Serber, et al. A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol Cell Biol. 2002 Dec;22(24):8601-11. [Content Brief]

[5]. Pamela Ghioni, et al. Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. Mol Cell Biol. 2002 Dec;22(24):8659-68. [Content Brief]

[6]. A Yang, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998 Sep;2(3):305-16. [Content Brief]

[7]. Kristina Heyne, et al. NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. Nucleic Acids Res. 2010 Jun;38(10):3159-71. [Content Brief]

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