Xenotropic and polytropic retrovirus receptor 1

Definition:

Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.

References:

[1]. Donatella Giovannini, et al. Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans. Cell Rep. 2013 Jun 27;3(6):1866-73. [Content Brief]

[2]. Rebekka Wild, et al. Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains. Science. 2016 May 20;352(6288):986-90. [Content Brief]

[3]. Andrea Legati, et al. Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nat Genet. 2015 Jun;47(6):579-81. [Content Brief]

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