XK-related protein 8

Definition:

[XK-related protein 8, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (By similarity). Has no effect on calcium-induced exposure of phosphatidylserine. Promotes myoblast differentiation and survival.; (Microbial infection) Incorporated into Ebola virus-like particles, where its phospholipid scramblase activity is required to promote phosphatidylserine exposure on the surface of viral particles. Externalization of phosphatidylserine on the surface of viral particles is required for uptake by host cells.

References:

[1]. Go-Woon Kim, et al. Xk-related protein 8 regulates myoblast differentiation and survival. FEBS J. 2017 Nov;284(21):3575-3588. [Content Brief]

[2]. Jun Suzuki, et al. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science. 2013 Jul 26;341(6144):403-6. [Content Brief]

[3]. Jun Suzuki, et al. Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. J Biol Chem. 2014 Oct 31;289(44):30257-30267. [Content Brief]

[4]. Asuka Nanbo, et al. Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles. PLoS Pathog. 2018 Jan 16;14(1):e1006848. [Content Brief]

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