2. PROTAC
  3. PROTAC Linkers
  4. Biotin-EDA

Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-EDA Chemical Structure

Biotin-EDA Chemical Structure

CAS No. : 111790-37-5

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Based on 1 publication(s) in Google Scholar

Biotin-EDA Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-EDA Related Antibodies
Molecular Weight

286.39

Formula

C12H22N4O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCCN)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (174.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4917 mL 17.4587 mL 34.9174 mL
5 mM 0.6983 mL 3.4917 mL 6.9835 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.49%

COA (245 KB) HNMR (118 KB) RP-HPLC (218 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4917 mL 17.4587 mL 34.9174 mL 87.2935 mL
5 mM 0.6983 mL 3.4917 mL 6.9835 mL 17.4587 mL
10 mM 0.3492 mL 1.7459 mL 3.4917 mL 8.7294 mL
15 mM 0.2328 mL 1.1639 mL 2.3278 mL 5.8196 mL
20 mM 0.1746 mL 0.8729 mL 1.7459 mL 4.3647 mL
25 mM 0.1397 mL 0.6983 mL 1.3967 mL 3.4917 mL
30 mM 0.1164 mL 0.5820 mL 1.1639 mL 2.9098 mL
40 mM 0.0873 mL 0.4365 mL 0.8729 mL 2.1823 mL
50 mM 0.0698 mL 0.3492 mL 0.6983 mL 1.7459 mL
60 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4549 mL
80 mM 0.0436 mL 0.2182 mL 0.4365 mL 1.0912 mL
100 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.8729 mL
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Biotin-EDA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-EDA111790-37-5PROTAC LinkersInhibitorinhibitorinhibit

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