2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG2-C4-alkyne

Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG2-C4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Biotin-PEG2-C4-alkyne Chemical Structure

Biotin-PEG2-C4-alkyne Chemical Structure

CAS No. : 1011268-28-2

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Based on 1 publication(s) in Google Scholar

Biotin-PEG2-C4-alkyne Related Antibodies

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Description

Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG2-C4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG2-C4-alkyne Related Antibodies
Molecular Weight

468.61

Formula

C22H36N4O5S
CAS No.
SMILES

O=C(NCCOCCOCCNC(CCCC#C)=O)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Biotin-PEG2-C4-alkyne Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG2-C4-alkyne1011268-28-2PROTAC LinkersPROTAC LinkerInhibitorinhibitorinhibit

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