Biotin-PEG3-NHS ester

Name: Biotin-PEG3-NHS ester
Brand: MedChemExpress
SKU: HY-130291
Rating: 4.5 (1 reviews)

Cat. No.: HY-130291 Purity: 99.35%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

For research use only. We do not sell to patients.

Biotin-PEG3-NHS ester Chemical Structure

CAS No. : 1253286-56-4

Size	Price	Stock	Quantity
25 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
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Description

Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

544.62

Formula

C₂₃H₃₆N₄O₉S

CAS No.

1253286-56-4

Appearance

Solid

Color

White to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (183.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8361 mL	9.1807 mL	18.3614 mL
5 mM	0.3672 mL	1.8361 mL	3.6723 mL
10 mM	0.1836 mL	0.9181 mL	1.8361 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.35%

Select Batch:

Data Sheet (240 KB) SDS (392 KB)

COA (243 KB) HNMR (293 KB) RP-HPLC (206 KB) MS (185 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8361 mL	9.1807 mL	18.3614 mL	45.9036 mL
	5 mM	0.3672 mL	1.8361 mL	3.6723 mL	9.1807 mL
	10 mM	0.1836 mL	0.9181 mL	1.8361 mL	4.5904 mL
	15 mM	0.1224 mL	0.6120 mL	1.2241 mL	3.0602 mL
	20 mM	0.0918 mL	0.4590 mL	0.9181 mL	2.2952 mL
	25 mM	0.0734 mL	0.3672 mL	0.7345 mL	1.8361 mL
	30 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5301 mL
	40 mM	0.0459 mL	0.2295 mL	0.4590 mL	1.1476 mL
	50 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.9181 mL
	60 mM	0.0306 mL	0.1530 mL	0.3060 mL	0.7651 mL
	80 mM	0.0230 mL	0.1148 mL	0.2295 mL	0.5738 mL
	100 mM	0.0184 mL	0.0918 mL	0.1836 mL	0.4590 mL