2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG7-amine

Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG7-amine Chemical Structure

Biotin-PEG7-amine Chemical Structure

CAS No. : 1334172-76-7

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5 mg USD 40 In-stock
10 mg USD 62 In-stock
25 mg USD 125 In-stock
50 mg USD 200 In-stock
100 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

Biotin-PEG7-amine Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

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Description

Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG7-amine Related Antibodies
Molecular Weight

594.76

Formula

C26H50N4O9S
CAS No.
Appearance

Solid-Liquid Mixture

Color

White to off-white

SMILES

O=C(NCCOCCOCCOCCOCCOCCOCCOCCN)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (140.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6814 mL 8.4068 mL 16.8135 mL
5 mM 0.3363 mL 1.6814 mL 3.3627 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6814 mL 8.4068 mL 16.8135 mL 42.0338 mL
5 mM 0.3363 mL 1.6814 mL 3.3627 mL 8.4068 mL
10 mM 0.1681 mL 0.8407 mL 1.6814 mL 4.2034 mL
15 mM 0.1121 mL 0.5605 mL 1.1209 mL 2.8023 mL
20 mM 0.0841 mL 0.4203 mL 0.8407 mL 2.1017 mL
25 mM 0.0673 mL 0.3363 mL 0.6725 mL 1.6814 mL
30 mM 0.0560 mL 0.2802 mL 0.5605 mL 1.4011 mL
40 mM 0.0420 mL 0.2102 mL 0.4203 mL 1.0508 mL
50 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.8407 mL
60 mM 0.0280 mL 0.1401 mL 0.2802 mL 0.7006 mL
80 mM 0.0210 mL 0.1051 mL 0.2102 mL 0.5254 mL
100 mM 0.0168 mL 0.0841 mL 0.1681 mL 0.4203 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Biotin-PEG7-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG7-amine1334172-76-7PROTAC LinkersInhibitorinhibitorinhibit

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