Biotin-PEG7-Maleimide

Cat. No.: HY-156377 Purity: 98.60%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Biotin-PEG7-Maleimide is a biotinylation reagent that reacts with thiol groups (SH). Biotin-PEG7-Maleimide can be used as Drug-Linker Conjugates for ADCs.

For research use only. We do not sell to patients.

Biotin-PEG7-Maleimide Chemical Structure

CAS No. : 1898221-65-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Biotin-PEG7-Maleimide is a biotinylation reagent that reacts with thiol groups (SH). Biotin-PEG7-Maleimide can be used as Drug-Linker Conjugates for ADCs^[1].

Molecular Weight

745.88

Formula

C₃₃H₅₅N₅O₁₂S

CAS No.

1898221-65-2

Appearance

Solid

Color

Colorless to off-white

SMILES

O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (134.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3407 mL	6.7035 mL	13.4070 mL
5 mM	0.2681 mL	1.3407 mL	2.6814 mL
10 mM	0.1341 mL	0.6703 mL	1.3407 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.60%

Select Batch:

Data Sheet (263 KB) SDS (251 KB)

COA (241 KB) HNMR (301 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. R James Christie, et al. Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides. J Control Release. 2015 Dec 28;220(Pt B):660-70. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3407 mL	6.7035 mL	13.4070 mL	33.5175 mL
	5 mM	0.2681 mL	1.3407 mL	2.6814 mL	6.7035 mL
	10 mM	0.1341 mL	0.6703 mL	1.3407 mL	3.3517 mL
	15 mM	0.0894 mL	0.4469 mL	0.8938 mL	2.2345 mL
	20 mM	0.0670 mL	0.3352 mL	0.6703 mL	1.6759 mL
	25 mM	0.0536 mL	0.2681 mL	0.5363 mL	1.3407 mL
	30 mM	0.0447 mL	0.2234 mL	0.4469 mL	1.1172 mL
	40 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.8379 mL
	50 mM	0.0268 mL	0.1341 mL	0.2681 mL	0.6703 mL
	60 mM	0.0223 mL	0.1117 mL	0.2234 mL	0.5586 mL
	80 mM	0.0168 mL	0.0838 mL	0.1676 mL	0.4190 mL
	100 mM	0.0134 mL	0.0670 mL	0.1341 mL	0.3352 mL