2. PROTAC
  3. PROTAC Linkers
  4. Bis-Biotin-PEG23

Bis-Biotin-PEG23 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bis-Biotin-PEG23 Chemical Structure

Bis-Biotin-PEG23 Chemical Structure

CAS No. : 293298-36-9

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Based on 1 publication(s) in Google Scholar

Bis-Biotin-PEG23 Related Antibodies

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Description

Bis-Biotin-PEG23 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-Biotin-PEG23 Related Antibodies
Molecular Weight

1525.90

Formula

C68H128N6O27S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2C(CSC2CCCCC(NCCOCCOCCNC(CCCCC3SCC(N4)C3NC4=O)=O)=O)N1.[22]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

Methanol : 125 mg/mL (81.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6554 mL 3.2768 mL 6.5535 mL
5 mM 0.1311 mL 0.6554 mL 1.3107 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 0.6554 mL 3.2768 mL 6.5535 mL 16.3838 mL
5 mM 0.1311 mL 0.6554 mL 1.3107 mL 3.2768 mL
10 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6384 mL
15 mM 0.0437 mL 0.2185 mL 0.4369 mL 1.0923 mL
20 mM 0.0328 mL 0.1638 mL 0.3277 mL 0.8192 mL
25 mM 0.0262 mL 0.1311 mL 0.2621 mL 0.6554 mL
30 mM 0.0218 mL 0.1092 mL 0.2185 mL 0.5461 mL
40 mM 0.0164 mL 0.0819 mL 0.1638 mL 0.4096 mL
50 mM 0.0131 mL 0.0655 mL 0.1311 mL 0.3277 mL
60 mM 0.0109 mL 0.0546 mL 0.1092 mL 0.2731 mL
80 mM 0.0082 mL 0.0410 mL 0.0819 mL 0.2048 mL
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Bis-Biotin-PEG23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-Biotin-PEG23293298-36-9PROTAC LinkersInhibitorinhibitorinhibit

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