2. PROTAC
  3. PROTAC Linkers
  4. Bis-PEG14-acid

Bis-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bis-PEG14-acid Chemical Structure

Bis-PEG14-acid Chemical Structure

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Based on 1 publication(s) in Google Scholar

Bis-PEG14-acid Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Bis-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-PEG14-acid Related Antibodies
Molecular Weight

734.82

Formula

C32H62O18
Appearance

Solid-Liquid Mixture

Color

White to off-white

SMILES

OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 350 mg/mL (476.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3609 mL 6.8044 mL 13.6088 mL
5 mM 0.2722 mL 1.3609 mL 2.7218 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3609 mL 6.8044 mL 13.6088 mL 34.0219 mL
5 mM 0.2722 mL 1.3609 mL 2.7218 mL 6.8044 mL
10 mM 0.1361 mL 0.6804 mL 1.3609 mL 3.4022 mL
15 mM 0.0907 mL 0.4536 mL 0.9073 mL 2.2681 mL
20 mM 0.0680 mL 0.3402 mL 0.6804 mL 1.7011 mL
25 mM 0.0544 mL 0.2722 mL 0.5444 mL 1.3609 mL
30 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1341 mL
40 mM 0.0340 mL 0.1701 mL 0.3402 mL 0.8505 mL
50 mM 0.0272 mL 0.1361 mL 0.2722 mL 0.6804 mL
60 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5670 mL
80 mM 0.0170 mL 0.0851 mL 0.1701 mL 0.4253 mL
100 mM 0.0136 mL 0.0680 mL 0.1361 mL 0.3402 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bis-PEG14-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-PEG14-acidPROTAC LinkersInhibitorinhibitorinhibit

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