Bis-propargyl-PEG2

Cat. No.: HY-133191: FAQs
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Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Bis-propargyl-PEG2 Chemical Structure

CAS No. : 126422-57-9

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5 g	USD 300	Ask For Quote & Lead Time
10 g	USD 510	Ask For Quote & Lead Time
25 g	USD 1020	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
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Description

Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers^[1]^[2]. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

Bis-propargyl-PEG2 can be used in the synthesis of demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

182.22

Formula

C₁₀H₁₄O₃

CAS No.

126422-57-9

Appearance

Liquid (Density: 1.011±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

C#CCOCCOCCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shenoi RA, et al. Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators. Biomacromolecules. 2012 Oct 8;13(10):3018-30. [Content Brief]

[2]. Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.