Bis-sulfone-PEG12-NHS ester 

Bis-sulfone-PEG12-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.

1197.36

C₅₆H₈₀N₂O₂₂S₂

2055105-51-4

O=S(C1=CC=C(C)C=C1)(CC(C(C2=CC=C(C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O)=O)C=C2)=O)CS(C4=CC=C(C)C=C4)(=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.