2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. bisSP1

bisSP1 is an antibody agent conjugates linker. bisSP1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

bisSP1 Chemical Structure

bisSP1 Chemical Structure

CAS No. : 2253947-15-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 140 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg USD 650 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

bisSP1 Related Antibodies

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  • References

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Description

bisSP1 is an antibody agent conjugates linker[1]. bisSP1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Molecular Weight

325.37

Formula

C12H23N9O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[N-]=[N+]=NCCC(N[C@@H](CCCCN)C(NCCCN=[N+]=[N-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (307.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0734 mL 15.3671 mL 30.7342 mL
5 mM 0.6147 mL 3.0734 mL 6.1468 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.39%

COA (243 KB) HNMR (204 KB) RP-HPLC (230 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0734 mL 15.3671 mL 30.7342 mL 76.8356 mL
5 mM 0.6147 mL 3.0734 mL 6.1468 mL 15.3671 mL
10 mM 0.3073 mL 1.5367 mL 3.0734 mL 7.6836 mL
15 mM 0.2049 mL 1.0245 mL 2.0489 mL 5.1224 mL
20 mM 0.1537 mL 0.7684 mL 1.5367 mL 3.8418 mL
25 mM 0.1229 mL 0.6147 mL 1.2294 mL 3.0734 mL
30 mM 0.1024 mL 0.5122 mL 1.0245 mL 2.5612 mL
40 mM 0.0768 mL 0.3842 mL 0.7684 mL 1.9209 mL
50 mM 0.0615 mL 0.3073 mL 0.6147 mL 1.5367 mL
60 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.2806 mL
80 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.9604 mL
100 mM 0.0307 mL 0.1537 mL 0.3073 mL 0.7684 mL
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bisSP1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

bisSP12253947-15-6bisSP 1bisSP-1ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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