2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. BMH-22

BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types.

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BMH-22 Chemical Structure

BMH-22 Chemical Structure

CAS No. : 309726-06-5

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BMH-22 Related Antibodies

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Description

BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].

Molecular Weight

251.33

Formula

C16H17N3
CAS No.
SMILES

CC1=C2N=C3N=C(C=C(C3=C(C2=CC(C)=C1)N)C)C
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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BMH-22 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMH-22309726-06-5BMH22BMH 22DNA/RNA SynthesisbenzonaphthyridinRNA polymerase IPol Itranscriptionp53nucleolar markernucleolusRPA194rRNA synthesis45S RrnaanticancerInhibitorinhibitorinhibit

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HY-118723
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