2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. BMS-1233

BMS-1233 is an orally active inhibitor for programmed cell death-ligand 1 (PD-L1), with IC50 of 14.5 nM. BMS-1233 promotes cell death of HepG2 in a Jurkat T cell and HepG2 cell co-culture model, exhibits antitumor activity against melanoma in mouse model.

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BMS-1233 Chemical Structure

BMS-1233 Chemical Structure

CAS No. : 2447065-99-6

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BMS-1233 Related Antibodies

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Description

BMS-1233 is an orally active inhibitor for programmed cell death-ligand 1 (PD-L1), with IC50 of 14.5 nM. BMS-1233 promotes cell death of HepG2 in a Jurkat T cell and HepG2 cell co-culture model, exhibits antitumor activity against melanoma in mouse model[1].

Molecular Weight

581.10

Formula

C35H33ClN2O4
CAS No.
SMILES

N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=CC=C4)=C3C)=C(C=C2CN5CCCCC5C(O)=O)Cl)=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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BMS-1233 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-12332447065-99-6BMS1233BMS 1233PD-1/PD-L1PD-1/Programmed death-ligand 1Sprague-Dawley ratHepG2JurkatCT26orally activeB16-F10Inhibitorinhibitorinhibit

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