2. Membrane Transporter/Ion Channel
  3. Na+/H+ Exchanger (NHE)
  4. BMS-284640

BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats..

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BMS-284640 Chemical Structure

BMS-284640 Chemical Structure

CAS No. : 230640-88-7

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BMS-284640 Related Antibodies

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Description

BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats.[1].

IC50 & Target

IC50: 9 nM (NHE-1), 1.8 μM (NHE-2)[1]
Molecular Weight

273.33

Formula

C15H19N3O2
CAS No.
SMILES

O=C([C@H]1C(C)(C)[C@@H]1C2=C3CCOC3=CC=C2)NC(N)=N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-284640 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-284640230640-88-7BMS284640BMS 284640Na+/H+ Exchanger (NHE)Sodium/hydrogen ExchangerSodium-hydrogen ExchangerInhibitorinhibitorinhibit

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