2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. BMS-639623

BMS-639623 is a potent and orally activeCCR3 antagonist with an IC50 of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC50=38 pM). BMS-639623 can be used for the research of asthma.

For research use only. We do not sell to patients.

BMS-639623 Chemical Structure

BMS-639623 Chemical Structure

CAS No. : 675122-44-8

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BMS-639623 Related Antibodies

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

BMS-639623 is a potent and orally activeCCR3 antagonist with an IC50 of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC50=38 pM). BMS-639623 can be used for the research of asthma[1].

IC50 & Target[1]

CCR3

0.3 nM (IC50)

Molecular Weight

481.57

Formula

C25H32FN7O2
CAS No.
SMILES

O=C(NC1=CC=CC(C2=NN=NN2C)=C1)N[C@H](C)[C@@H](O)CN3C[C@H](CC4=CC=C(F)C=C4)CCC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-639623 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-639623675122-44-8BMS639623BMS 639623CCRCC chemokine receptoreosinophil chemotaxisasthmaCCR3 antagonistInhibitorinhibitorinhibit

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