1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. nAChR
  3. BMS-933043

BMS-933043 is a potent and selective α7 nACh receptor partial agonist. BMS-933043 attenuates the cognitive impairment in mice and can be utilized in research related to cognitive dysfunction in schizophrenia.

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BMS-933043 Chemical Structure

BMS-933043 Chemical Structure

CAS No. : 1221973-93-8

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Description

BMS-933043 is a potent and selective α7 nACh receptor partial agonist. BMS-933043 attenuates the cognitive impairment in mice and can be utilized in research related to cognitive dysfunction in schizophrenia[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
100 nM
Compound: 1c; BMS-933043
Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method
Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method
[PMID: 28337332]
HEK293 EC50
300 nM
Compound: 1c; BMS-933043
Agonist activity at human alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method
Agonist activity at human alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method
[PMID: 28337332]
Molecular Weight

325.37

Formula

C16H19N7O

CAS No.
SMILES

C1(CC2)[C@@]3(OC(NC4=NC=NC(N5C=CN=C5)=C4)=NC3)CN2CC1

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Product Name:
BMS-933043
Cat. No.:
HY-W062702
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