2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. BMS-986118

BMS-986118 is a potent, orally active, and selective GPR40 agonist with an EC50 of 0.07 µM. BMS-986118 has dual insulinotropic and GLP-1 secretory effects, resulting in robust plasma glucose lowering effects in acute animal models.

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BMS-986118 Chemical Structure

BMS-986118 Chemical Structure

CAS No. : 1610562-74-7

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BMS-986118 Related Antibodies

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Description

BMS-986118 is a potent, orally active, and selective GPR40 agonist with an EC50 of 0.07 µM. BMS-986118 has dual insulinotropic and GLP-1 secretory effects, resulting in robust plasma glucose lowering effects in acute animal models[1].

IC50 & Target

IC50: 0.07 µM (GPR40)[1]
Molecular Weight

540.96

Formula

C25H28ClF3N4O4
CAS No.
SMILES

COC1=CC(N2CC[C@H]([C@@H](C2)C)OC3=CC=C(C=C3)N4[C@H]([C@@H](C(C(F)(F)F)=N4)C)CC(O)=O)=C(C=N1)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-986118 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9861181610562-74-7BMS986118BMS 986118Free Fatty Acid ReceptorFFARoralGLP-1 secretoryinsulinotropicacute animal modelsInhibitorinhibitorinhibit

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