2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. BMS-986188

BMS-986188 is a selective positive allosteric modulator of δ-opioid receptor with an EC50 of 0.05 μM.

For research use only. We do not sell to patients.

BMS-986188 Chemical Structure

BMS-986188 Chemical Structure

CAS No. : 1776115-10-6

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5 mg USD 80 In-stock
10 mg USD 130 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

BMS-986188 Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMS-986188 is a selective positive allosteric modulator of δ-opioid receptor with an EC50 of 0.05 μM[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
> 10 μM
Compound: 10, BMS-986188
Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after 90 mins by beta-arrestin recruitment assay
Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after 90 mins by beta-arrestin recruitment assay
[PMID: 25901762]
CHO EC50
0.05 μM
Compound: 10, BMS-986188
Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response after 90 mins by beta-arrestin recruitment assay
Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response after 90 mins by beta-arrestin recruitment assay
[PMID: 25901762]
Molecular Weight

535.47

Formula

C30H31BrO4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C2=C(CC(C)(C1)C)OC(CC(C)(CC3=O)C)=C3C2C4=CC=C(C=C4)OCC5=CC=CC=C5Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (116.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8675 mL 9.3376 mL 18.6752 mL
5 mM 0.3735 mL 1.8675 mL 3.7350 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8675 mL 9.3376 mL 18.6752 mL 46.6880 mL
5 mM 0.3735 mL 1.8675 mL 3.7350 mL 9.3376 mL
10 mM 0.1868 mL 0.9338 mL 1.8675 mL 4.6688 mL
15 mM 0.1245 mL 0.6225 mL 1.2450 mL 3.1125 mL
20 mM 0.0934 mL 0.4669 mL 0.9338 mL 2.3344 mL
25 mM 0.0747 mL 0.3735 mL 0.7470 mL 1.8675 mL
30 mM 0.0623 mL 0.3113 mL 0.6225 mL 1.5563 mL
40 mM 0.0467 mL 0.2334 mL 0.4669 mL 1.1672 mL
50 mM 0.0374 mL 0.1868 mL 0.3735 mL 0.9338 mL
60 mM 0.0311 mL 0.1556 mL 0.3113 mL 0.7781 mL
80 mM 0.0233 mL 0.1167 mL 0.2334 mL 0.5836 mL
100 mM 0.0187 mL 0.0934 mL 0.1868 mL 0.4669 mL
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BMS-986188 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9861881776115-10-6BMS986188BMS 986188Opioid ReceptorInhibitorinhibitorinhibit

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