BN-82451 dihydrochloride 

BN-82451 dihydrochloride, an orally active and CNS-penetrated antioxidant and a multitargeting neuroprotective agent, exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis^[1][2].

BN82451 exhibits IC₅₀ values of 0.08 and 0.05 µM for COX-1 and COX-2, respectively^[2].
BN82451 acts via three major pathways involved in neuronal death: excitotoxicity, oxidative stress, and inflammation, and is also a mitochondrial protective agent^[2].
BN82451 inhibits lipid peroxidation in rat brain microsomes in a concentration-dependent manner with an IC₅₀ value of 0.54 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BN-82451 improves motor ability and attenuates neurodegeneration in a mouse model of Huntington’s disease (HD)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

391.40

C₁₈H₂₈Cl₂N₂OS

663172-95-0

OC1=C(C(C)(C)C)C=C(C2=CSC(CN)=N2)C=C1C(C)(C)C.Cl.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Anthony J Hannan, et al. Novel therapeutic targets for Huntington's disease. Expert Opin Ther Targets. 2005 Aug;9(4):639-50.  [Content Brief]

  [2]. Pierre Etienne Chabrier, et al. Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent. CNS Drug Rev. 2007 Fall;13(3):317-32.  [Content Brief]