2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Boc-NH-PEG1-CH2CH2COOH

Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs.

For research use only. We do not sell to patients.

Boc-NH-PEG1-CH2CH2COOH Chemical Structure

Boc-NH-PEG1-CH2CH2COOH Chemical Structure

CAS No. : 1260092-44-1

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Based on 1 publication(s) in Google Scholar

Boc-NH-PEG1-CH2CH2COOH Related Antibodies

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Description

Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-NH-PEG1-CH2CH2COOH Related Antibodies
Molecular Weight

233.26

Formula

C10H19NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(OC(NCCOCCC(O)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

COA (242 KB) HNMR (116 KB)

Handling Instructions (2659 KB)
References
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Boc-NH-PEG1-CH2CH2COOH Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-NH-PEG1-CH2CH2COOH1260092-44-1ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerPROTACPEG-basedlinkerAlkyletherInhibitorinhibitorinhibit

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