2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. BODIPY FL thalidomide

BODIPY FL thalidomide is a high-affinity fluorescent probe for the human cereblon protein with a Kd value of 3.6 nM[1]

For research use only. We do not sell to patients.

BODIPY FL thalidomide Chemical Structure

BODIPY FL thalidomide Chemical Structure

CAS No. : 2740620-18-0

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5 mg USD 450 In-stock
10 mg USD 700 In-stock
25 mg USD 1400 In-stock
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Based on 1 publication(s) in Google Scholar

BODIPY FL thalidomide Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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  • Purity & Documentation

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Description

BODIPY FL thalidomide is a high-affinity fluorescent probe for the human cereblon protein with a Kd value of 3.6 nM[1]

IC50 & Target

Cereblon

 

Molecular Weight

732.58

Formula

C37H43BF2N6O7
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCCNC(CCC4=CC=C5C=C6C(C)=CC(C)=[N]6[B+3]([F-])([N-]54)[F-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (136.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3650 mL 6.8252 mL 13.6504 mL
5 mM 0.2730 mL 1.3650 mL 2.7301 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.20%

SDS (251 KB)

COA (250 KB) HNMR (143 KB) RP-HPLC (203 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3650 mL 6.8252 mL 13.6504 mL 34.1260 mL
5 mM 0.2730 mL 1.3650 mL 2.7301 mL 6.8252 mL
10 mM 0.1365 mL 0.6825 mL 1.3650 mL 3.4126 mL
15 mM 0.0910 mL 0.4550 mL 0.9100 mL 2.2751 mL
20 mM 0.0683 mL 0.3413 mL 0.6825 mL 1.7063 mL
25 mM 0.0546 mL 0.2730 mL 0.5460 mL 1.3650 mL
30 mM 0.0455 mL 0.2275 mL 0.4550 mL 1.1375 mL
40 mM 0.0341 mL 0.1706 mL 0.3413 mL 0.8531 mL
50 mM 0.0273 mL 0.1365 mL 0.2730 mL 0.6825 mL
60 mM 0.0228 mL 0.1138 mL 0.2275 mL 0.5688 mL
80 mM 0.0171 mL 0.0853 mL 0.1706 mL 0.4266 mL
100 mM 0.0137 mL 0.0683 mL 0.1365 mL 0.3413 mL
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BODIPY FL thalidomide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BODIPY FL thalidomide2740620-18-0E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisInhibitorinhibitorinhibit

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