Bonannione A  (Synonyms: 6-Geranylnaringenin; Mimulone)

Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity^[1][2][3].

Bonannione A (0-80 µM; 12, 24 hours) significantly inhibits cell proliferation in a dose- and time-dependent way in cancer cell lines^[2].
Bonannione A (0-60 µM; 24 hours) triggers caspase-dependent apoptosis in A549 cells. Bonannione A increases accumulation of cells at the apoptotic sub-G1 phase and the number of cells at G2/M phase^[2].
Bonannione A (60 µM, 24 h) triggers autophagy without impairment of autophagic flux in A549 cells. Bonannione A remarkably reduced p53 levels^[2].
Bonannione A (60 µM, 0-24 h) remarkably decreased the levels of p53 and phospho-mTOR^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bonannione A (25 mg/kg; gavage; 48 and 24 h prior to DSS and every 24 h on the following days; for 5days) ameliorates the symptoms of colitis and delayed their onset^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

408.49

C₂₅H₂₈O₅

97126-57-3

O=C1C[C@H](OC2=C1C(O)=C(C(O)=C2)C/C=C(CC/C=C(C)\C)\C)C3=CC=C(C=C3)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lai-Bin Zhang, et al. Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulate. Nat Prod Bioprospect. 2016 Feb;6(1):25-30.  [Content Brief]

  [2]. Hyun-Kyu An, et al. Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells. PLoS One. 2014 Dec 9;9(12):e114607.  [Content Brief]

  [3]. Zora Vochyánová, et al. Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats. Fitoterapia. 2015 Mar;101:201-7.  [Content Brief]