Bonducellpin D

Cat. No.: HY-N2949 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M^pro and MERS-CoV M^pro, with an K_i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro.

For research use only. We do not sell to patients.

Bonducellpin D Chemical Structure

CAS No. : 197781-85-4

Size	Price	Stock	Quantity
1 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Ki: 467.11 nM (SARS-CoV Mpro), 284.86 nM (MERS-CoV Mpro)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	12 μM Compound: Bonducellpin D	Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay	[PMID: 24303808]
HeLa	IC₅₀	> 50 μM Compound: Bonducellpin D	Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay	[PMID: 24303808]
HepG2	IC₅₀	8 μM Compound: Bonducellpin D	Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay	[PMID: 24303808]
K562	IC₅₀	> 50 μM Compound: Bonducellpin D	Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay	[PMID: 24303808]
RAW264.7	IC₅₀	25.4 μM Compound: Caesalpinin H	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by griess reagent assay Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by griess reagent assay	[PMID: 36215157]

Molecular Weight

404.45

Formula

C₂₂H₂₈O₇

CAS No.

197781-85-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@]([C@H]1OC(C)=O)(C(C)(CC2)C)[C@@]([C@](CC(OC=C3)=C3[C@]45[H])([H])[C@@]4([H])[C@@]1([H])OC5=O)([C@H]2O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (277 KB) SDS (392 KB)

COA (261 KB) HNMR (132 KB)

Handling Instructions (2659 KB)

References

[1]. Gurung AB, et, al. Unravelling lead antiviral phytochemicals for the inhibition of SARS-CoV-2 M pro enzyme through in silico approach. Life Sci. 2020 Aug 15;255:117831. [Content Brief]

[2]. Zheng Y, et, al. Caesalminaxins A-L, cassane diterpenoids from the seeds of Caesalpinia minax. J Nat Prod. 2013 Dec 27; 76(12): 2210-8. [Content Brief]

[3]. Jiang RW, et, al. Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax. Bioorg Med Chem. 2002 Jul;10(7):2161-70. [Content Brief]

Bonducellpin D Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bonducellpin D197781-85-4SARS-CoVSARS coronavirusfuranoditerpenoidlactoneCaesalpiniaminaxMERS-CoVanti-cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Bonducellpin D

Customer Review

Bonducellpin D Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Bonducellpin D Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report