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Borocaptate sodium  (Synonyms: BSH)

Cat. No.: HY-142041 Purity: ≥95.0%
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Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity.

For research use only. We do not sell to patients.

Borocaptate sodium Chemical Structure

Borocaptate sodium Chemical Structure

CAS No. : 144885-51-8

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Based on 1 publication(s) in Google Scholar

Borocaptate sodium Related Antibodies

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Description

Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity[1][2].

In Vitro

Borocaptate sodium (60 μg 10B/mL, 24 hours) combined with BSO (HY-106376) enhances boron uptake and inhibits cell viability in mouse squamous carcinoma cells, rat glioma cells, and hamster lung cells, with boron uptake increasing as cell viability decreases[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Borocaptate sodium Related Antibodies

Cell Viability Assay[3]

Cell Line: Mouse squamous cell carcinoma SCCVII, rat glioma cell line C6, Chinese hamster V79 cells.
Concentration: 60 μg 10B/mL (Each milliliter of Borocaptate sodium solution contains 60 µg of boron-10 isotope (10B))
Incubation Time: 24 h
Result: Increased boron uptake in tumor cells by 19.2%-34.4% and enhanced the inhibitory effect on cell viability (combined with BSO (HY-106376), a glutathione inhibitor).
In Vivo

Borocaptate sodium (55 mg/kg, i.v., single dose) selectively targets intracranial tumors in dogs and inhibits their growth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneous intracranial tumor-bearing dogs (primarily gliomas, mixed breed dogs, typically between 5-10 years old, weight 20-30 kg)[2]
Dosage: 55 mg/kg
Administration: Intravenous injection (i.v.), single dose
Result: Resulted in boron concentrations of 35.9 µg/g in the tumor at 2 hours, 22.5 µg/g at 6 hours, and 7.0 µg/g at 12 hours. The boron concentration in the tumor was higher than that in normal brain tissue, with a favorable tumor-to-brain ratio.
Molecular Weight

219.87

Formula

B12H12Na2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

SB1234[BH]567[BH]89%10[BH]%11%12%13[BH]85%14[BH]%11%15%16[BH]%12%17%18[BH]%139%19[BH]%1061[BH]%19%172[BH]%15%183[BH]%14%1674.[Na].[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 175 mg/mL (795.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5481 mL 22.7407 mL 45.4814 mL
5 mM 0.9096 mL 4.5481 mL 9.0963 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5481 mL 22.7407 mL 45.4814 mL 113.7036 mL
5 mM 0.9096 mL 4.5481 mL 9.0963 mL 22.7407 mL
10 mM 0.4548 mL 2.2741 mL 4.5481 mL 11.3704 mL
15 mM 0.3032 mL 1.5160 mL 3.0321 mL 7.5802 mL
20 mM 0.2274 mL 1.1370 mL 2.2741 mL 5.6852 mL
25 mM 0.1819 mL 0.9096 mL 1.8193 mL 4.5481 mL
30 mM 0.1516 mL 0.7580 mL 1.5160 mL 3.7901 mL
40 mM 0.1137 mL 0.5685 mL 1.1370 mL 2.8426 mL
50 mM 0.0910 mL 0.4548 mL 0.9096 mL 2.2741 mL
60 mM 0.0758 mL 0.3790 mL 0.7580 mL 1.8951 mL
80 mM 0.0569 mL 0.2843 mL 0.5685 mL 1.4213 mL
100 mM 0.0455 mL 0.2274 mL 0.4548 mL 1.1370 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Borocaptate sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Borocaptate144885-51-8BSHOthersBoron neutron capture therapy (BNCT)anticancer activityInhibitorinhibitorinhibit

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