Bozepinib

Cat. No.: HY-118032: FAQs
Data Sheet Handling Instructions

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Bozepinib is a PKR (RNA-dependent protein kinase) activator and potently inhibits the HER-2 signaling pathway as well as JNK and ERK kinases. Bozepinib induces PKR-mediated apoptosis and synergizes with IFNα to trigger apoptosis, autophagy and senescence. Bozepinib also demonstrates in vivo antitumor and antimetastatic efficacy in xenografted nude mice.

For research use only. We do not sell to patients.

Bozepinib Chemical Structure

CAS No. : 1207993-83-6

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ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	1.825 μM Compound: (RS)-14	Cytotoxicity against human MCF10A cells after 3 days by SRB assay Cytotoxicity against human MCF10A cells after 3 days by SRB assay	[PMID: 21126804]
MCF7	IC₅₀	0.355 μM Compound: (RS)-14	Cytotoxicity against human MCF7 cells expressing wild type p53 and ras mutant after 3 days by SRB assay Cytotoxicity against human MCF7 cells expressing wild type p53 and ras mutant after 3 days by SRB assay	[PMID: 21126804]
MDA-MB-231	IC₅₀	0.166 μM Compound: (RS)-14	Cytotoxicity against human MDA-MB-231 cells expressing high level of p53 after 3 days by SRB assay Cytotoxicity against human MDA-MB-231 cells expressing high level of p53 after 3 days by SRB assay	[PMID: 21126804]

Molecular Weight

521.33

Formula

C₂₀H₁₄Cl₂N₆O₅S

CAS No.

1207993-83-6

SMILES

O=S(N1CC(OCC2=CC=CC=C21)N3C=NC4=C3N=C(N=C4Cl)Cl)(C5=CC=C(C=C5)[N+]([O-])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Marchal JA, et al. Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence. Drug Des Devel Ther. 2013 Oct 29;7:1301-13. [Content Brief]

[2]. Ramírez A, et al. HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. Oncotarget. 2014 Jun 15;5(11):3590-606. [Content Brief]

Bozepinib Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bozepinib1207993-83-6ApoptosisAutophagyJNKERKc-Jun N-terminal kinaseExtracellular signal regulated kinasesHER-2tumorcancerapoptosisautophagysenescenceInhibitorinhibitorinhibit

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