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BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation).

For research use only. We do not sell to patients.

BPH-652 Chemical Structure

BPH-652 Chemical Structure

CAS No. : 157124-84-0

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1 mg USD 340 In-stock
5 mg USD 850 In-stock
10 mg USD 1300 In-stock
25 mg USD 2650 In-stock
50 mg USD 4250 In-stock
100 mg USD 6900 In-stock
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Based on 1 publication(s) in Google Scholar

BPH-652 Related Antibodies

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Description

BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation)[1].

IC50 & Target

Ki: 1.5 nM (CrtM).
IC50: 100-300 nM (S. aureus pigment formation)[1].
In Vivo

BPH-652 treatment (0.5 mg twice per day (days −1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureus bacterial counts in the kidneys of the mice than those of the control group (P < 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A systemic S. aureus infection model in mice[1].
Dosage: 0.5 mg twice per day (days −1, 0, 1, and 2).
Administration: Intraperitoneal injection.
Result: S. aureus bacterial counts in the kidneys of the mice treated with BPH-652 were significantly lower than those of the control group.
Molecular Weight

500.63

Formula

C16H16K3O7PS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C(P(O[K])(O[K])=O)CCCC1=CC=CC(OC2=CC=CC=C2)=C1)(O[K])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (49.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9975 mL 9.9874 mL 19.9748 mL
5 mM 0.3995 mL 1.9975 mL 3.9950 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9975 mL 9.9874 mL 19.9748 mL 49.9371 mL
5 mM 0.3995 mL 1.9975 mL 3.9950 mL 9.9874 mL
10 mM 0.1997 mL 0.9987 mL 1.9975 mL 4.9937 mL
15 mM 0.1332 mL 0.6658 mL 1.3317 mL 3.3291 mL
20 mM 0.0999 mL 0.4994 mL 0.9987 mL 2.4969 mL
25 mM 0.0799 mL 0.3995 mL 0.7990 mL 1.9975 mL
30 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.6646 mL
40 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2484 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BPH-652 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPH-652157124-84-0BPH652BPH 652OtherscholesterolInhibitorinhibitorinhibit

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