2. Metabolic Enzyme/Protease Others
  3. Mitochondrial Metabolism Others
  4. BPU17

BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration (nAMD) agent.

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BPU17 Chemical Structure

BPU17 Chemical Structure

CAS No. : 2198977-68-1

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BPU17 Related Antibodies

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Description

BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration (nAMD) agent[1].

Molecular Weight

252.70

Formula

C12H13ClN2O2
CAS No.
SMILES

ClC1=CC=C(NC(NC(C2CCC2)=O)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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BPU17 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPU172198977-68-1BPU 17BPU-17Mitochondrial MetabolismOthersPHB1EMTPHB1-PHB2 interactionRPEsantifibrotic activitynAMDInhibitorinhibitorinhibit

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