2. MAPK/ERK Pathway
  3. Raf
  4. BRAF V600E/CRAF-IN-2

BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases.

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BRAF V600E/CRAF-IN-2 Chemical Structure

BRAF V600E/CRAF-IN-2 Chemical Structure

CAS No. : 2499499-62-4

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BRAF V600E/CRAF-IN-2 Related Antibodies

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Description

BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].

Molecular Weight

549.59

Formula

C30H30F3N5O2
CAS No.
SMILES

CCN1CCN(CC1)C2=CC(C(F)(F)F)=CC(C(NC3=CC=CC(NC4=NC5=CC=CC(OC)=C5C=C4)=C3)=O)=C2
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Room temperature in continental US; may vary elsewhere.
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BRAF V600E/CRAF-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRAF V600E/CRAF-IN-22499499-62-4RafRaf kinasesapoptosiscell cycle arrestG0/G1 phasecancerInhibitorinhibitorinhibit

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