BRD4 D1-IN-1

Cat. No.: HY-142704: FAQs
Data Sheet Handling Instructions

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BRD4 D1-IN-1 is a selective BRD4 D1 inhibitor (IC₅₀<0.092 µM). BRD4 D1-IN-1 has 18 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC.

For research use only. We do not sell to patients.

BRD4 D1-IN-1 Chemical Structure

CAS No. : 2863623-98-5

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Description

BRD4 D1-IN-1 is a selective BRD4 D1 inhibitor (IC₅₀<0.092 µM). BRD4 D1-IN-1 has 18 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	14 μM Compound: 30	Cytotoxicity against human A549 cells assessed as viable cells incubated for 23 hrs by alamar blue assay Cytotoxicity against human A549 cells assessed as viable cells incubated for 23 hrs by alamar blue assay	[PMID: 35007061]

Molecular Weight

578.67

Formula

C₃₂H₃₇F₃N₆O

CAS No.

2863623-98-5

SMILES

CC(C1=CC=C(C(OC2=NC(C3=C(N=CN3[C@@H]4CN(CC4)CCN(C)C)C5=CC=C(C=C5)C(F)(F)F)=CC=N2)=C1)C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cui H, et al. A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. J Med Chem. 2022;65(3):2342-2360. [Content Brief]

BRD4 D1-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 D1-IN-12863623-98-5Epigenetic Reader DomainBET bromodomainselectivehigh affinityMM.1S cellsInhibitorinhibitorinhibit

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