BRD4 degrader-6

Cat. No.: HY-173327: FAQs
Data Sheet Handling Instructions Technical Support

BRD4 degrader-6 is a dimeric BDR4PROTAC degrader (DC₅₀: < 0.1 μM). BRD4 degrader-6 promotes the ubiquitination and degradation of BDR4 and has anticancer activity.

For research use only. We do not sell to patients.

BRD4 degrader-6 Chemical Structure

CAS No. : 3055207-38-7

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PROTACs Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description

BRD4 degrader-6 is a dimeric BDR4PROTAC degrader (DC₅₀: < 0.1 μM). BRD4 degrader-6 promotes the ubiquitination and degradation of BDR4 and has anticancer activity^[1].

IC₅₀ & Target

BRD4

<0.1 μM (DC₅₀)

In Vitro

BRD4 degrader-6 (example 1) (1.5 nM, Pre-treatment 2h, re-treatment 24h) can effectively degrade BDR4 in BRD4 HiBiT cells (DC₅₀: < 0.11 μM)^[1].
BRD4 degrader-6 relies on the reversibility of the bond to dissociate into monomers in vitro and in vivo, allowing them to enter cells and then re-form dimers inside the cells, where they then bind to target proteins and induce ubiquitin-mediated degradation of the target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1152.67

Formula

C₆₁H₇₁BClN₉O₇S₂

CAS No.

3055207-38-7

SMILES

ClC1=CC=C(C=C1)C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(NCC[C@@]56[C@@H]7C[C@H](C[C@@H]5OB(O6)C8=C(C=CC=C8)CCC(N[C@H](C(N9C[C@@H](C[C@H]9C(NCC%10=CC=C(C=C%10)C%11=C(N=CS%11)C)=O)O)=O)C(C)(C)C)=O)C7(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Harry Finch, et al. Dimer compounds. England. WO2024175905 2024-08-29

BRD4 degrader-6 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 degrader-63055207-38-7PROTACsEpigenetic Reader DomainBRD4HiBiT cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *