2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD4 Inhibitor-19

BRD4 Inhibitor-19 is a BET inhibitor with an IC50 of 55 nM for BRD4-BD1. BRD4 Inhibitor-19 can be used for multiple myeloma research.

For research use only. We do not sell to patients.

BRD4 Inhibitor-19 Chemical Structure

BRD4 Inhibitor-19 Chemical Structure

CAS No. : 2757865-63-5

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BRD4 Inhibitor-19 Related Antibodies

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Description

BRD4 Inhibitor-19 is a BET inhibitor with an IC50 of 55 nM for BRD4-BD1. BRD4 Inhibitor-19 can be used for multiple myeloma research[1].

IC50 & Target[1]

BD1

55 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
CT26 IC50
21.18 μM
Compound: 14
Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 33862375]
HepG2 IC50
19.49 μM
Compound: 14
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 33862375]
U-266 IC50
3.45 μM
Compound: 14
Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 33862375]
Molecular Weight

491.54

Formula

C29H25N5O3
CAS No.
SMILES

CC1=NOC(C)=C1C2=CC=C3C(C(N(C(N3C)=O)CC4=NN=C(O4)C5=CC=CC=C5)C6=CC=CC=C6)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRD4 Inhibitor-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 Inhibitor-192757865-63-5Epigenetic Reader DomainBET inhibitorMultiple myelomaMMInhibitorinhibitorinhibit

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