2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Breast cancer targeting peptide 18–4

Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide, with a Kd of 0.98 μM. The amino acid sequence of Breast cancer targeting peptide 18–4 is WxEAAYQrFL, and it is an analogue of P160 peptide (HY-P10789). When covalently conjugated with the anticancer peptide MccJ25, Breast cancer targeting peptide 18–4 significantly increases the cellular uptake of MccJ25 in breast cancer cells and enhances its anticancer activity. The covalent conjugate exhibits IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cells, respectively.

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Breast cancer targeting peptide 18–4 Chemical Structure

Breast cancer targeting peptide 18–4 Chemical Structure

CAS No. : 1332850-08-4

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Breast cancer targeting peptide 18–4 Related Antibodies

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Description

Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide, with a Kd of 0.98 μM. The amino acid sequence of Breast cancer targeting peptide 18–4 is WxEAAYQrFL, and it is an analogue of P160 peptide (HY-P10789). When covalently conjugated with the anticancer peptide MccJ25, Breast cancer targeting peptide 18–4 significantly increases the cellular uptake of MccJ25 in breast cancer cells and enhances its anticancer activity. The covalent conjugate exhibits IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cells, respectively[1].

Molecular Weight

1296.47

Formula

C63H89N15O15
CAS No.
Sequence

Trp-{d-Nle}-Glu-Ala-Ala-Tyr-Gln-{d-Arg}-Phe-Leu
Sequence Shortening

W-{d-Nle}-EAAYQ-{d-Arg}-FL
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Breast cancer targeting peptide 18–4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Breast cancer targeting peptide 18–41332850-08-4Microtubule/TubulinInhibitorinhibitorinhibit

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