Brefeldin A 4-O-nicotinate  (Synonyms: CHNQD-01228)

Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC₅₀ value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer^[1].

385.45

C₂₂H₂₇NO₅

3035018-34-6

O=C1O[C@@H](C)CCC/C=C/[C@@]2([H])[C@](C[C@@H](O)C2)([H])[C@H](OC(C3=CN=CC=C3)=O)/C=C/1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu JY, et al. Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer. J Nat Prod. 2025 Mar 28;88(3):830-841.