2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. BRL 52537 hydrochloride

BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage.

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BRL 52537 hydrochloride Chemical Structure

BRL 52537 hydrochloride Chemical Structure

CAS No. : 112282-24-3

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50 mg USD 420 In-stock
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Based on 1 publication(s) in Google Scholar

BRL 52537 hydrochloride Related Antibodies

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View All Opioid Receptor Isoform Specific Products:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage[1].

IC50 & Target

Ki: 0.24 nM (κ-Opioid receptor) and 1560 nM (μ-Opioid receptor)[1]
Molecular Weight

391.76

Formula

C18H25Cl3N2O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CC1=CC=C(C(Cl)=C1)Cl)N2CCCCC2CN3CCCC3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Methanol : 25 mg/mL (63.81 mM; Need ultrasonic)

DMSO : 5 mg/mL (12.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5526 mL 12.7629 mL 25.5258 mL
5 mM 0.5105 mL 2.5526 mL 5.1052 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 2.5526 mL 12.7629 mL 25.5258 mL 63.8146 mL
5 mM 0.5105 mL 2.5526 mL 5.1052 mL 12.7629 mL
10 mM 0.2553 mL 1.2763 mL 2.5526 mL 6.3815 mL
Methanol 15 mM 0.1702 mL 0.8509 mL 1.7017 mL 4.2543 mL
20 mM 0.1276 mL 0.6381 mL 1.2763 mL 3.1907 mL
25 mM 0.1021 mL 0.5105 mL 1.0210 mL 2.5526 mL
30 mM 0.0851 mL 0.4254 mL 0.8509 mL 2.1272 mL
40 mM 0.0638 mL 0.3191 mL 0.6381 mL 1.5954 mL
50 mM 0.0511 mL 0.2553 mL 0.5105 mL 1.2763 mL
60 mM 0.0425 mL 0.2127 mL 0.4254 mL 1.0636 mL
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BRL 52537 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRL 52537112282-24-3BRL52537BRL-52537Opioid Receptorκ-Opioid receptorsKORμ subtypeNO productionneuroprotectionstroke damageInhibitorinhibitorinhibit

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