2. PROTAC
  3. PROTAC Linkers
  4. Bromo-PEG8-Boc

Bromo-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bromo-PEG8-Boc Chemical Structure

Bromo-PEG8-Boc Chemical Structure

CAS No. : 1623792-00-6

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50 mg USD 32 In-stock
100 mg USD 61 In-stock
250 mg USD 74 In-stock
500 mg USD 148 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Bromo-PEG8-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Bromo-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromo-PEG8-Boc Related Antibodies
Molecular Weight

561.50

Formula

C23H45BrO10
CAS No.
Appearance

Liquid (Density: 1.18 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCOCCOCCBr
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 87.5 mg/mL (155.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7809 mL 8.9047 mL 17.8094 mL
5 mM 0.3562 mL 1.7809 mL 3.5619 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7809 mL 8.9047 mL 17.8094 mL 44.5236 mL
5 mM 0.3562 mL 1.7809 mL 3.5619 mL 8.9047 mL
10 mM 0.1781 mL 0.8905 mL 1.7809 mL 4.4524 mL
15 mM 0.1187 mL 0.5936 mL 1.1873 mL 2.9682 mL
20 mM 0.0890 mL 0.4452 mL 0.8905 mL 2.2262 mL
25 mM 0.0712 mL 0.3562 mL 0.7124 mL 1.7809 mL
30 mM 0.0594 mL 0.2968 mL 0.5936 mL 1.4841 mL
40 mM 0.0445 mL 0.2226 mL 0.4452 mL 1.1131 mL
50 mM 0.0356 mL 0.1781 mL 0.3562 mL 0.8905 mL
60 mM 0.0297 mL 0.1484 mL 0.2968 mL 0.7421 mL
80 mM 0.0223 mL 0.1113 mL 0.2226 mL 0.5565 mL
100 mM 0.0178 mL 0.0890 mL 0.1781 mL 0.4452 mL
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Bromo-PEG8-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromo-PEG8-Boc1623792-00-6PROTAC LinkersInhibitorinhibitorinhibit

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