2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRPF1B/TRIM24-IN-1

BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM.

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BRPF1B/TRIM24-IN-1 Chemical Structure

BRPF1B/TRIM24-IN-1 Chemical Structure

CAS No. : 1242907-48-7

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BRPF1B/TRIM24-IN-1 Related Antibodies

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Description

BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM[1].

IC50 & Target

BRPF1

0.34 μM (IC50)

BRPF2

1.75 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
MM1.S GI50
> 10 μM
Compound: 34
Cytotoxicity against human MM1S cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human MM1S cells after 72 hrs by CellTiter-Glo assay
[PMID: 25974391]
In Vitro

BRPF1B/TRIM24-IN-1 (compound 34) shows no significant cytotoxicity in breast cancer cell line MCF-7. BRPF1B/TRIM24-IN-1 has modest cytotoxicity on a panel of cancer cell lines (MM1S, RCH-ACH, JJN3, RKO) (GI50 > 10 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRPF1B/TRIM24-IN-1 Related Antibodies
Molecular Weight

499.54

Formula

C24H25N3O7S
CAS No.
SMILES

O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC=C(OC)C=C3)C=C(N4C)C(N(C)C4=O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRPF1B/TRIM24-IN-1 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRPF1B/TRIM24-IN-11242907-48-7Epigenetic Reader DomainTripartite motif 24 proteinTRIM24BRPF1BRPF2MM1SRCH-ACHJJN3RKOMCF-7Inhibitorinhibitorinhibit

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