Btk substrate peptide

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Btk substrate peptide is a peptide substrate corresponding to residues 217-229 of human Bruton’s tyrosine kinase (Btk), of which the tyrosine at residue 223 is the major autophosphorylation site of Btk. Btk substrate peptide is used as a substrate in in vitro kinase assays to evaluate the activity of Btk or other tyrosine kinases.

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Btk substrate peptide Chemical Structure

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Description	Btk substrate peptide is a peptide substrate corresponding to residues 217-229 of human Bruton’s tyrosine kinase (Btk), of which the tyrosine at residue 223 is the major autophosphorylation site of Btk. Btk substrate peptide is used as a substrate in in vitro kinase assays to evaluate the activity of Btk or other tyrosine kinases^[1].
Molecular Weight	1571.90
Formula	C₇₂H₁₁₄N₁₆O₁₉S₂
Sequence	Lys-Lys-Val-Val-Ala-Leu-Tyr-Asp-Tyr-Met-Pro-Met-Asn
Sequence Shortening	KKVVALYDYMPMN
SMILES	O=C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCSC)C(N3[C@@H](CCC3)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (257 KB) Handling Instructions (2659 KB)
References	[1]. Bence, et al. "Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit." Nature 389.6648 (1997): 296-299.