2. Immunology/Inflammation
  3. NO Synthase COX
  4. Buddlejasaponin IV

Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells.

For research use only. We do not sell to patients.

Buddlejasaponin IV Chemical Structure

Buddlejasaponin IV Chemical Structure

CAS No. : 139523-30-1

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Buddlejasaponin IV Related Antibodies

Top Publications Citing Use of Products

View All NO Synthase Isoform Specific Products:

View All Isoforms
nNOS iNOS eNOS

View All COX Isoform Specific Products:

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COX COX-1 COX-2 COX-3

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Description

Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells[1].

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
14.6 μM
Compound: 2
Cytotoxicity against human A375 cells after 48 hrs by SRB assay
Cytotoxicity against human A375 cells after 48 hrs by SRB assay
[PMID: 19467877]
A549 IC50
38.3 μM
Compound: 2
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 19467877]
ACHN IC50
7.9 μM
Compound: 2
Cytotoxicity against human ACHN cells after 48 hrs by SRB assay
Cytotoxicity against human ACHN cells after 48 hrs by SRB assay
[PMID: 19467877]
C32 IC50
26.9 μM
Compound: 2
Cytotoxicity against human C32 cells after 48 hrs by SRB assay
Cytotoxicity against human C32 cells after 48 hrs by SRB assay
[PMID: 19467877]
Caco-2 IC50
40.7 μM
Compound: 2
Cytotoxicity against human Caco-2 cells after 48 hrs by SRB assay
Cytotoxicity against human Caco-2 cells after 48 hrs by SRB assay
[PMID: 19467877]
COR-L23 IC50
0.4 μM
Compound: 2
Cytotoxicity against human COR-L23 cells after 48 hrs by SRB assay
Cytotoxicity against human COR-L23 cells after 48 hrs by SRB assay
[PMID: 19467877]
LNCaP IC50
> 50 μM
Compound: 2
Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay
Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay
[PMID: 19467877]
MCF7 IC50
> 50 μM
Compound: 2
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 19467877]
RAW264.7 IC50
10.6 μM
Compound: 2
Cytotoxicity against mouse RAW264.7 cells by MTT assay
Cytotoxicity against mouse RAW264.7 cells by MTT assay
[PMID: 19467877]
RAW264.7 IC50
4.2 μM
Compound: 2
Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
[PMID: 19467877]
In Vitro

Buddlejasaponin IV induces cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes[1].
Buddlejasaponin IV (BS-IV) exhibits anti-inflammatory effect of through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-κB inactivation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Buddlejasaponin IV Related Antibodies
Molecular Weight

943.12

Formula

C48H78O18
CAS No.
SMILES

C[C@]12[C@]3(C=C[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@H](O[C@@]6([H])[C@@H]([C@H]([C@@H](O)[C@@H](C)O6)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)O[C@]8([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]8O)CO)[C@@]5(C)CO)C)C)[C@@]9([H])[C@](CO3)(CCC(C)(C)C9)[C@@H](O)C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Buddlejasaponin IV Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Buddlejasaponin IV139523-30-1NO SynthaseCOXNitric oxide synthasesNOSCyclooxygenaseInhibitorinhibitorinhibit

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