Butriptyline (Synonyms: Butriptylene)

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Butriptyline (Butriptylene) is an orally active tricyclic antidepressant agent.

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Butriptyline Chemical Structure

CAS No. : 35941-65-2

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Description

Butriptyline (Butriptylene) is an orally active tricyclic antidepressant agent^[1].

In Vivo

Butriptyline (1000 mg/kg; in diet; 10 weeks) shows anti-obesity effect in mice^[1].
Butriptyline hydrochloride (2.5-30 mg/kg; i.p.; 10-15 day intervals) causes a dose dependent depression of the food reinforced responses and slightly depresses the avoidance reflex at the highest doses in male albino rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female CFLP mice, monosodium glutamate (MSG)-induced obesity model^[1]
Dosage:	1000 mg/kg
Administration:	In diet, 10 weeks
Result:	Significantly lowered the body weight.

Molecular Weight

293.45

Formula

C₂₁H₂₇N

CAS No.

35941-65-2

SMILES

CC(CN(C)C)CC1C2=CC=CC=C2CCC3=C1C=CC=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dulloo AG, et al. Screening of drugs for thermogenic anti-obesity properties: antidepressants. Ann Nutr Metab. 1987;31(2):69-80. [Content Brief]

[2]. Molinengo L, et al. The action of imipramine, amitriptyline, doxepin and butriptyline in an operant conditioning schedule. Psychopharmacologia. 1972;24(2):247-57. [Content Brief]

Butriptyline Related Classifications

Neurological Disease

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butriptyline35941-65-2ButriptyleneOthersantidepressant agentorally activeanti-obesityInhibitorinhibitorinhibit

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