BY27

Cat. No.: HY-126325: FAQs
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BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity.

For research use only. We do not sell to patients.

BY27 Chemical Structure

CAS No. : 2247236-59-3

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Biological Activity
Purity & Documentation
References
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Description

BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity^[1].

IC₅₀ & Target^[1]

BRD2 BD2

3.1 nM (Ki)

BRD2 BD1

95.5 nM (Ki)

BRD3 BD2

5.3 nM (Ki)

BRD3 BD1

77.9 nM (Ki)

BRD4 BD2

7.3 nM (Ki)

BRD4 BD1

80 nM (Ki)

BRD2 BD2

1.2 nM (Kd)

BRD2 BD1

45 nM (Kd)

BRD3 BD2

2.6 nM (Kd)

BRD3 BD1

12 nM (Kd)

BRD4 BD2

3.5 nM (Kd)

BRD4 BD1

26 nM (Kd)

BRDT BD2

3 nM (Kd)

BRDT BD1

64 nM (Kd)

Cellular Effect

Cell Line	Type	Value	Description	References
MM1.S	IC₅₀	16.7 nM Compound: 47; BY27	Antiproliferative activity against human MM1S cells assessed as cell growth inhibition after 4 days by CCK8 assay Antiproliferative activity against human MM1S cells assessed as cell growth inhibition after 4 days by CCK8 assay	[PMID: 31461688]
MV4-11	IC₅₀	27 nM Compound: 47; BY27	Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition after 4 days by CCK8 assay Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition after 4 days by CCK8 assay	[PMID: 31461688]

Molecular Weight

404.90

Formula

C₂₂H₂₁ClN₆

CAS No.

2247236-59-3

SMILES

CN1N=CC(C2=CC=C(N3C(CC[C@H]4NC5=CC=C(Cl)C=C5)=NN=C3C)C4=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen D, et al. Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins. Eur J Med Chem. 2019 Aug 21;182:111633. [Content Brief]

BY27 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BY272247236-59-3BY 27BY-27Epigenetic Reader DomainInhibitorinhibitorinhibit

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