c-Met/HDAC-IN-2

Cat. No.: HY-143462: FAQs
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c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC₅₀s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance.

For research use only. We do not sell to patients.

c-Met/HDAC-IN-2 Chemical Structure

CAS No. : 2740495-53-6

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

HDAC1

18.49 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.22 μM Compound: 14x	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 32738414]
HCT-116	IC₅₀	0.22 μM Compound: 14x	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 32738414]
MCF7	IC₅₀	1.59 μM Compound: 14x	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 32738414]

In Vitro

c-Met/HDAC-IN-2 (compound 14X) (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549^[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) induces of cancer cell apoptosis in a dose-dependent manner^[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) significantly causes G2/M-phase arrest in HCT-116 cells in a dose dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	HCT-116, MCF-7 and A549^[1]
Concentration:	0-20 μM
Incubation Time:	72 hours
Result:	Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC₅₀s of 0.22 ± 0.09 μM, 1.59 ± 0.06 μM and 0.22 ± 0.04 μM, respectively.

Apoptosis Analysis

Cell Line:	HTC-116^[1]
Concentration:	0.2, 1 and 5 μM
Incubation Time:	48 hours
Result:	The percentage of apoptotic cells was 4.19%, 11.53% and 21.48% at 0.2 μM, 1.0 μM and 5.0 μM, respectively.

Cell Cycle Analysis

Cell Line:	HTC-116^[1]
Concentration:	0.2, 1 and 5 μM
Incubation Time:	48 hours
Result:	Significantly caused G2/M-phase arrest in HCT-116 cells in a dose dependent manner.

Molecular Weight

623.66

Formula

C₃₄H₃₃N₅O₇

CAS No.

2740495-53-6

SMILES

O=C(C1=NN(C2=CC=CC=C2)C=CC1=O)NC3=CC=C(OC4=CC=NC5=CC(OCCCCCCC(NO)=O)=C(OC)C=C45)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hu H, Chen F, Dong Y, et al. Discovery of Novel c-Mesenchymal-Epithelia transition factor and histone deacetylase dual inhibitors. Eur J Med Chem. 2020;204:112651. [Content Brief]

c-Met/HDAC-IN-2 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met/HDAC-IN-22740495-53-6HDACc-Met/HGFRApoptosisHistone deacetylasesAnticancerAntiproliferative activitiesHCT-116MCF-7A549Inhibitorinhibitorinhibit

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