2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. c-Met-IN-13

c-Met-IN-13 is a potent c-Met inhibitor with an IC50 value of 2.43 nM. c-Met-IN-13 shows excellent cytotoxicity for cancer cells. c-Met-IN-13 shows antiproliferative activity in a concentration- and time- dependent manner. c-Met-IN-13 has the potential for the research of cancer.

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c-Met-IN-13 Chemical Structure

c-Met-IN-13 Chemical Structure

CAS No. : 2377724-93-9

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c-Met-IN-13 Related Antibodies

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Description

c-Met-IN-13 is a potent c-Met inhibitor with an IC50 value of 2.43 nM. c-Met-IN-13 shows excellent cytotoxicity for cancer cells. c-Met-IN-13 shows antiproliferative activity in a concentration- and time- dependent manner. c-Met-IN-13 has the potential for the research of cancer[1].

Cellular Effect
Cell Line Type Value Description References
HT-29 IC50
0.2 μM
Compound: 10m
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32200199]
MDA-MB-231 IC50
0.42 μM
Compound: 10m
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32200199]
MKN-45 IC50
0.26 μM
Compound: 10m
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32200199]
NCI-H460 IC50
0.14 μM
Compound: 10m
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32200199]
In Vitro

c-Met-IN-13 (compound 10m) shows cytotoxic activities with IC50s of 0.14, 0.20, 0.26 µM for H460, HT-29, MKN-45, respectively[1].
c-Met-IN-13 shows tyrosine kinases selectively with IC50s of 4.42, 6.15, 18.64, 295, 540, >10000, 2.43 nM for c-kit, Flt-3,Ron, VEGFR-2, Flt-4, EGFR, C-Met, respectively[1].
c-Met-IN-13 (0-300 µg/ml; 72 h) shows antiproliferative activity in a concentration and time dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

c-Met-IN-13 Related Antibodies
Molecular Weight

550.55

Formula

C30H28F2N2O6
CAS No.
SMILES

O=C(OC(C(C)(C)C)C(NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C(F)=C1)=O)C4=CC=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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c-Met-IN-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met-IN-132377724-93-9c-Met/HGFRcytotoxicityconcentration- and time- dependentH460 cellsanticancerInhibitorinhibitorinhibit

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